Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as the 5.5-point road favorite, per the latest NFL odds.

The Lions aim to avoid consecutive losses for the first time since 2022 when they travel to an injury-plagued Commanders team.

The Denver Broncos are highly motivated to stack a 10th straight win with the Las Vegas Raiders on the docket this week. In the Broncos' first Raiders matchup in Week 10, the offense needs to continue building toward becoming a good, reliable unit, as they've done in the two games since.

The 2025 NFL schedule has moved into double digits as we reach Week 10 of the year. Teams are starting to position themselves for the playoffs, trying to make up for struggles in the first half of the year, or starting to look toward 2026 already.

SportsLine's model simulated Chiefs vs. Texans 10,000 times and released its NFL best anytime TD scorers props for Kansas City vs. Houston on SNF

The Houston Texans and Kansas City Chiefs meet for Sunday Night Football with an 8:20 p.m. Et kickoff at Arrowhead Stadium. Here are the best prop bets for the game.